Professor McArdle started nurse training in 1988 at Beaumont Hospital, Dublin. She qualified in 1991 and worked as a Staff Nurse there for a year. In 1992, Charlotte moved to Belfast to work in Musgrave Park Hospital where she remained until 1998. In 1996 Charlotte completed a BSC in Health Studies.

In 1998, Charlotte moved to the Royal Group of Hospitals to take up a Ward Sister post where she achieved the Nursing Times/Foundation of Nursing Studies Leadership Award in 1999. She also completed an MSc in Nursing at Queen’s University, Belfast in 1999. At the end of 1999, Charlotte moved into Senior Management at the Royal Group of Hospitals and remained in senior management posts until 2004, where she was appointed Deputy Director of Nursing at the Royal Group of Hospitals.

In 2007, Charlotte was appointed Director of Primary Care, Older People and Executive Director of Nursing in South Eastern Trust, and in April 2013, Charlotte took up post as Chief Nursing Officer with the Department of Health, Social Services and Public Safety.

Charlotte has a strong commitment to person centred practice and evidencing improved outcomes for patients and clients, particularly regarding safety, quality and experience.